Eye-irritation-test of Surface Active Agents by Experimental Animal

Surfactants - Surface Active Agents

The definition for a detergent is a cleaning agent. The main cleaning agent used in earlier days was soap. This term means a compound formed from the reaction of a fatty acid with a base such as caustic soda, forming the sodium soap of the acid. The more commonly used cleaning agent in this day and age is the synthetic detergent (SYNDET) which is a formulation such as TIDE or FAB. The essential...

Silicone Surface-Active Agents

1 Subgroup 3 . Eye Irritation

Comparison of human skin irritation patch test data with in vitro skin irritation assays and animal data.

BACKGROUND Efforts to replace the rabbit skin irritation test have been underway for many years, encouraged by the EU Cosmetics Directive and REACH. Recently various in vitro tests have been developed, evaluated and validated. OBJECTIVE A key difficulty in confirming the validity of in vitro methods is that animal data are scarce and of limited utility for prediction of human effects, which a...

The Influence of Intravenously Administered Surface-active Agents on the Development of Experimental Atherosclerosis in Rabbits

A study was made of the relationship of blood lipids to the development of experimental atherosclerosis. Rabbits fed a diet containing cholesterol were found to develop hyperlipemia characterized by a great increase in blood cholesterol and a much lesser increase in blood phospholipids; after several weeks they manifested conspicuous atherosclerosis of the aorta, as has often been observed by o...